Elevated C-Reactive Protein in Patients With Obstructive Sleep Apnea

By A. Shamsuzzaman, M. Winnicki, P. Lanfranchi, R. Wolk, T. Kara, V. Accurso, Virend K. Somers. Circulation, 2002

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Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. (2007, background): “The hypoxia response in adipose tissue may explain insulin resistance induced by a hypoxia environment or systemic hypoxia (39, 48 , 50).”
Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. (2009, background): “In fact, OSA may contribute to the pathogenesis of HTN and increased inflammation and CRP ( 61 ).”
Obstructive sleep apnea: implications for cardiac and vascular disease. (2003, background): “Indeed, patients with sleep apnea have increased levels of interleukin 6, tumor necrosis factor ,(62) and C-reactive protein.(63) C-reactive protein itself may contribute to vascular disease and dysfunction by inhibiting nitric oxide synthase(64) and increasing expression of cell adhesion molecules.”
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. (2004, background): “They also support the hypothesis that one way in which CRP is elevated in patients with untreated obstructive sleep apnea is through deprivation of restorative sleep ( 23 ).”