New Neurons Follow the Flow of Cerebrospinal Fluid in the Adult Brain

By K. Sawamoto, Hynek Wichterle, Ó. González-Pérez, J. Cholfin, M. Yamada, Nathalie Spassky, N. Murcia, Jose Manuel García-Verdugo, O. Marín, John L. Rubenstein and 3 more. 2006

810 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Developmental Neuroscience, Molecular Biology

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Citations in the corpus

Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, positive): “Nondividing ependymal cells lining the ventricle are multiciliated, and their motile cilia contribute to the flow of cerebrospinal fluid (Spassky et al., 2005; Sawamoto et al., 2006; Carlén et al., 2009; Mirzadeh et al., 2010a).”
Hedgehog Signaling in the Subventricular Zone Is Required for Both the Maintenance of Stem Cells and the Migration of Newborn Neurons (2007, background): “Recent studies have shown that the choroid plexus cells secrete Slit protein in vitro (Nguyen-Ba-Charvet et al., 2004) and in vivo (Sawamoto et al., 2006).”
The biophysics of neuronal growth (2010, background): “[28] or molecules bound to cellular or extracellular surfaces”
Adult neurogenesis and functional plasticity in neuronal circuits (2006, background): “They show that polarized epithelia and motile cilia in the brain serve as important conveyors of directional information for neuroblast migratio”
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells (2011, background): “, 2010) and Slit guidance of neuroblasts in adult brain (Sawamoto et al., 2006).”
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. (2006, background): “Since ependymal cells have been implicated in directing SVZ neuroblast migration toward the OB (Sawamoto et al., 2006), it was not surprising that ependymal defects together with SCJ neuroblast apoptosis led to P14 mutant mice having smaller OBs that contained fewer interneurons than control mice…”
New Neurons Clear the Path of Astrocytic Processes for Their Rapid Migration in the Adult Brain (2010, positive): “It is generally accepted that Slit proteins assist in the directional migration of new neurons born in the adult SVZ: Slit1 and Slit2 secreted from the choroid plexus and the septum direct neurons rostrally, toward the OB (Hu, 1999; Hu and Rutishauser, 1996; Sawamoto et al., 2006; Wu et al., 1999).”
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. (2010, positive): “This flow guides the migration of neural progenitor cells from the subventricular zone to the olfactory bulb (Sawamoto et al., 2006) and is also essential for spontaneous generation of planar cell polarity of the ependymal cell themselves (Breunig et al., 2010).”
Adult neurogenesis and the olfactory system. (2009, background): “Within the SVZ, the flow of cerebral spinal fluid (CSF) may influence neuroblast migration.”