Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives.

By C. G. Spruijt, Felix A Gnerlich, A. H. Smits, T. Pfaffeneder, P. Jansen, Christina Bauer, M. Münzel, Mirko Wagner, Markus Müller, Fariha Khan and 11 more. 2013

973 citations recorded by the source corpus.

Subfields: Molecular Biology

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In Molecular Biology

1. Hao Wu
2. Yi Zhang
3. Hongjun Song
4. Guo-li Ming
5. K. Helin
6. Dirk Schübeler
7. Jussi Taipale
8. E. Raiber

Citations in the corpus

• Impact of cytosine methylation on DNA binding specificities of human transcription factors (2017, background): “This class included TFs that have previously been reported to weakly prefer mCpG, such as CEBPB (40), KLFs (19, 20, 41), and RFX5 (20) (fig.”
• Mapping and elucidating the function of modified bases in DNA (2017, background): “5caC-specific binding proteins have been identified from proteomics experiments that support roles for these cytosine modifications in chromatin remodeling and transcriptional regulation.(31,32,33) Another study found that double stranded 5fC-containing DNA could covalently interact with DNMT1; the ”
• DNA methylation presents distinct binding sites for human transcription factors (2013, background): “For example, a recent study (Spruijt et al., 2013) employed a generic methylated DNA probe to pull down potential methylated DNA-binding proteins in mouse cell lysates, resulted in the identification of 19 proteins.”
• Role of TET enzymes in DNA methylation, development, and cancer (2016, background): “Instead, the much less abundant cytosine species 5fC and 5caC appear to interact with numerous proteins, including TDG, p53, DNA repair factors, chromatin remodeling factors, and forkhead box TFs (Iurlaro et al. 2013; Spruijt et al. 2013).”
• Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions (2014, positive): “For example, TDG and a number of DNA repair proteins were found to specifically bind to 5fCand 5caC-containing DNA oligonucleotides (Spruijt et al., 2013).”
• Structural basis for Klf4 recognition of methylated DNA (2014, methodology): “Using a DNA pull-down approach combined with quantitative mass spectrometry, three Klf proteins (Klf2, Klf4 and Klf5) were identified as 5mC readers in mouse embryonic stem (ES) cells (21).”