The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome

By D. Sela, Jarrod Chapman, A. Adeuya, Junhyong Kim, Feng Chen, T. Whitehead, Alla L. Lapidus, D. Rokhsar, C. Lebrilla, J. Bruce German and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2008

893 citations recorded by the source corpus.

Subfields: Food Science, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/02d41775019efad89a28a674099d6779247befe5

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Citations in the corpus

The Hologenome Concept: Human, Animal and Plant Microbiota (2014, background): “…(Akman et al. 2002; Nogge 1981; Wilson et al. 2010; Brune 2011) Bovine rumen (Mizrahi 2011) Humans (Sekirov et al. 2010; Pluznicka et al. 2013; Sela et al. 2008) Plants (Remy et al. 1994; Bidartondo 2005; Lugtenberg and Kamilova 2009; Bloemberg and Lugtenberg 2001) Development Hydra (Rahat…”
Human milk glycobiome and its impact on the infant gastrointestinal microbiota (2010, background): “Six of these cluster I lipoproteins exhibit a pronounced evolutionary divergence relative to other SBP Family 1 proteins in bifidobacteria (17), suggesting a possible relationship with milk oligosaccharides.”
Carbohydrate metabolism in Bifidobacteria (2011, background): “Many of the gene clusters involved in sugar metabolism contain LacI-type regulators, which suggest that the transcription of such gene clusters are subject to substratedependent repression [63, 83, 107, 108, 124, 126 ].”
Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. (2016, neutral): “Indeed, by analyzing the taxonomic origin of genes belonging to a bona fide HMO gene cluster (Sela et al., 2008), we showed that although the average abundance of HMO utilization genes is approximately equal across the three countries (mean ± SD in RPKM: Finland 460 ± 372, Estonia 462 ± 331, Russia ”
Succession of microbial consortia in the developing infant gut microbiome (2010, background): “During the initial few months of a milk diet, bacteria such as Bifidobacteria, highly adapted to process milk oligosaccharides, can be abundant (3).”
Mechanisms and consequences of intestinal dysbiosis (2017, background): “are specialized at fermenting complex fucosylated oligosaccharides [108], which explains their prominence in the gut of breastfed infants.”
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota (2017, background): “lular solute binding proteins and permeases of ABC transporter systems) of HMOs (232).”
Human milk oligosaccharides: every baby needs a sugar mama. (2012, background): “Sequencing of the B. infantis genome revealed entire gene clusters that control the expression of specific glycosidases, sugar transporters and glycanbinding proteins dedicated to HMO utilization (Sela et al. 2008).”
Bifidobacteria and Their Role as Members of the Human Gut Microbiota (2016, background): “Fifteen out of the 20 patients remained in remission throughout the trial, suggesting that administration of this bacterial cocktail is beneficial in maintaining remission from ulcerative colitis (Venturi et al., 1999; Gionchetti et al., 2000).”
Diversity of Bifidobacteria within the Infant Gut Microbiota (2012, background): “infantis) are genetically adapted to utilize hostproduced glycans like mucins and human milk oligosaccharides [50–53].”
Bifidobacteria-mediated immune system imprinting early in life (2020, methodology): “Human breastmilk contains abundant Human Milk Oligosaccharides (HMOs) and these are not digestible by humans who lack necessary glucosidases (Sela and Mills, 2010).”
The human milk microbiota: origin and potential roles in health and disease. (2013, background): “It has been previously demonstrated that selected bifidobacerial and lactobacilli phylotypes use specific HMOs secreted early n the lactation cycle [15]; more recently, the genome sequences f two bifidobacterial strains have revealed several adaptations for ilk utilization within the infant microbio”