Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells

By C. Gaggioli, S. Hooper, Cristina Hidalgo-Carcedo, R. Grosse, J. Marshall, K. Harrington, Erik Sahai. Nature Cell Biology, 2007

1,554 citations recorded by the source corpus.

Subfields: Cell Biology, Immunology and Allergy

View Paper: https://www.semanticscholar.org/paper/02b2ae9251642b394972022d4ebc0cb0acdd1be4

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Citations in the corpus

Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “In agreement and as suggested by recent studies in mice, mesenchymal cells could constitute the driving force for epithelial cells to fulfil local invasion and distantmetastasis [159–161].”
E-cadherin–integrin crosstalk in cancer invasion and metastasis (2013, background): “Instead, advanced cancers can display plasticity with respect to morphological characteristics and the modes of migration and invasion they use; these can be altered and adapted according to interactions with and signals they receive from, the local tumour environment (Gaggioli et al., 2007; Giampie”
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion (2017, background): “Clustering of α(5)β(1) integrins determines adhesion strength whereas α(v)β(3) and talin enable mechanotransduction.”
Role of hypoxia in cancer therapy by regulating the tumor microenvironment (2019, background): “Studies have shown that cancer-associated fibroblasts (CAFs) and myeloid cells assist in the process of tumor metastasis [45].”
Adhesion signaling – crosstalk between integrins, Src and Rho (2009, background): “Second, integrin α5β1 seems to be essential for the contractility mediated by RhoA and ROCK, which is required for ECM remodeling in invading cancer-associated fibroblasts in order to create invasive tracks that guide the carcinoma cells that follow behind (Gaggioli et al., 2007).”
Cancer as an overhealing wound: an old hypothesis revisited (2008, background): “This suggests that tumour fibroblasts can enable cancer-cell invasion, even if these cancer cells do not undergo EM”
Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. (2012, background): “Moreover, ECM remodeling by CAFs 1542 Cell 151, 1542–1556, December 21, 2012 ª2012 Elsevier Inc. is essential for tumor cell invasion and metastasis (Gaggioli et al., 2007; Goetz et al., 2011).”