Stages in the development of Parkinson’s disease-related pathology

By H. Braak, E. Ghebremedhin, Udo Rüb, H. Bratzke, K. Del Tredici. Cell and Tissue Research, 2004

2,690 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/f2b3b1c5f870ce0fb2a00179213043275cc32c19

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In Neurology

Citations in the corpus

Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration (2007, neutral): “the major neurodegenerative diseases [9, 10, 52].”
The clinical symptoms of Parkinson's disease (2016, background): “induction sites and advancing in a topographically predictable sequence within the nervous system (Braak et al. 2004).”
Parkinson's disease and parkinsonism: neuropathology. (2012, background): “Based on the distribution ofa-synuclein pathology, Braak and co-workers have proposed a staging scheme for PD (Braak et al. 2004).”
Unified Staging System for Lewy Body Disorders: Correlation with Nigrostriatal Degeneration, Cognitive Impairment and Motor Dysfunction (2009, background): “Other authors have offered reasons for this special vulnerability, citing thinly myelinated and lengthy axons [15], an unusually high degree of neuronal plasticity [28, 48] or the spatial proximity to the external environment, with its associated exposure to toxins and infectious agents [14, 43, 58]”
Wearable Assistant for Parkinson’s Disease Patients With the Freezing of Gait Symptom (2010, background): “PD is a common neurological disorder caused by the progressive loss of dopaminergic and other subcortical neurons [1].”
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease (2013, background): “Furthermore, it has been proposed that PD begins in the brain-stem and a wave of pathology progresses rostrally, when the midbrain is reached, SNc dopamine neurons degenerate and the major motor symptoms of PD ensue (Braak et al., 2002, 2004).”
Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. (2007, background): “This staging system posits a temporal sequence of synuclein pathology in the brain beginning in the medulla and eventually ascending to more rostral structures (Braak et al., 2003, 2004).”