Macrophage Diversity Enhances Tumor Progression and Metastasis

By Binzhi Qian, J. Pollard. Cell, 2010

4,995 citations recorded by the source corpus.

There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression. During tumor initiation they create an inflammatory environment that is mutagenic and which promotes growth. As tumors progress to malignancy, macrophages stimulate angiogenesis, enhance tumor cell migration, invasion, and suppress anti-tumor immunity. At metastatic sites macrophages prepare the target tissue for arrival of tumor cells and then a different subpopulation of macrophages promotes tumor cell extravasation, survival, and subsequent growth. Specialized subpopulations of macrophages may represent important new therapeutic targets.

Subfields: Immunology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0241a2b9fa4c8197c1f903605e537668b216a57c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. A. Mantovani
2. J. Pollard
3. A. Sica
4. Lisa M. Coussens
5. P. Allavena
6. J. Joyce
7. F. Balkwill
8. M. Karin

In Molecular Biology

1. Lisa M. Coussens
2. J. Joyce
3. A. Mantovani
4. J. Pollard
5. Guido Kroemer
6. Rakesh K. Jain
7. A. Sica
8. M. Karin

In Oncology

1. A. Mantovani
2. J. Pollard
3. Lisa M. Coussens
4. A. Sica
5. P. Allavena
6. J. Joyce
7. M. Karin
8. F. Balkwill

Citations in the corpus

• Coordinated regulation of myeloid cells by tumours (2012, background): “Although the contribution of myeloid cells to tumour pathogenesis has been recognized for over 100 years, only during the past two decades has their crucial role in promoting tumour angiogenesis, cell invasion and metastasis been appreciated (reviewed in Ref”
• The spleen in local and systemic regulation of immunity (2013, background): “This activity might be deleterious to the host because TAMs can stimulate tumor growth, and their density predicts patient survival in several cancer types (Qian and Pollard, 2010; Steidl et al., 2010; DeNardo et al., 2011).”
• Differential Macrophage Programming in the Tumor Microenvironment (2012, neutral): “Thus, in addition to differentiation of TAMs, from either Tie2+ [89] or other monocyte precursors [83] that may preferentially home to specific localizations, one can envision that integration of these distinct signals result in production of an array of TAM populations/phenotypes with unique tumor-”
• Diversity, Mechanisms and Significance of Macrophage Plasticity (2019, background): “Thus, mononuclear phagocyte intrinsinc and extrinsic metabolic characteristics contribute to shaping TAM function (128).”
• Therapeutic siRNA silencing in inflammatory monocytes (2011, background): “Silencing of CCR2 reduces tumor-associated macrophages The host immune system's role in cancer progression, including tumor vascularization, growth, metastasis and resistance to chemotherapy, is well establishe”
• Tumor-associated macrophages: from mechanisms to therapy (2014, background): “Furthermore, in most large-scale transcriptome analysis, macrophages have a mixed phenotype expressing both M1 and M2 markers (Qian and Pollard, 2010).”
• Regulatory mechanisms of PD-1/PD-L1 in cancers (2024, background): “Tumor-associated macrophages (TAMs) refer to a specific type of macrophage that infiltrates into tumors, typically characterized by two polarization states but whose functional phenotype is closer to that of M2 macrophages [103].”