Control of oncogenesis and cancer therapy resistance by the transcription factor NF-κB

By A. Baldwin. 2001

1,432 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/0231877cb395971d6317c61f258af1e117f56c91

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Valerie M. Weaver
2. F. Giancotti
3. Mina J. Bissell
4. P. Johnston
5. A. Sica
6. J. Adams
7. Scott W. Lowe
8. A. Mantovani

In Molecular Biology

1. Valerie M. Weaver
2. Zena Werb
3. A. Sica
4. Scott W. Lowe
5. P. Allavena
6. A. Mantovani
7. M. Soengas
8. F. Giancotti

In Oncology

1. A. Mantovani
2. A. Sica
3. P. Allavena
4. Valerie M. Weaver
5. Zena Werb
6. C. Porta
7. Scott W. Lowe
8. F. Giancotti

Citations in the corpus

• Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells (2001, background): “The results of this study found that EPO actions were mediated by the nuclear translocation of NF- B, a well established regulator of immune and inflammatory responses (Ghosh et al., 1998), and implicated in antiapoptotic and pro-proliferative aspects of oncogenesis (Baldwin, 2001).”
• Modulation of NF-κB Activity by Exchange of Dimers (2003, background): “In turn,ous genes controlling immune response, cell growth, IKK phosphorylates p100, thus directing its polyubiqui-apoptosis, and tissue differentiation (Baldwin, 2001; tination and processing (Senftleben et al., 2001).”
• Role of tumor-associated macrophages in tumor progression and invasion (2006, background): “NF-κB regulates expression of adhesion molecules [24, 25] and cell-surface metalloproteases, such as MMP-9 and MMP-2 [ 26 ].”
• Apoptosis A Link between Cancer Genetics and Chemotherapy (2002, background): “For example, inactivationaction implies that restoring p53 activity in p53 null tu- mors, or activating apoptotic pathways that are directly of NF- B by overexpression of I- B can restore sensitivity of tumor cells to chemotherapy (Baldwin, 2001).”
• beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. (2002, background): “…activation also drives resistance to chemo- and radiation ther- mutant I B , which is resistant to proteolytic degradation, nu- clear translocation of p65 did not occur (data not shown) and allapy (Baldwin, 2001; Baeuerle and Baltimore, 1996) and modifies CANCER CELL : SEPTEMBER 2002 209 Figure 6.”
• Molecular mechanisms of drug resistance (2005, background): “NF-κB has been connected with multiple pathways involved in oncogenesis, including cell cycle regulation and apoptosis [243,244].”
• Apoptosis and Molecular Targeting Therapy in Cancer (2014, background): “Conflict of Interests The authors declare that there is no conflict of interests regarding the publication of this paper.”