Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.
By J. Adolfsson, O. Borge, David Bryder, K. Theilgaard-Mönch, Ing-Britt Åstrand-Grundström, E. Sitnicka, Yutaka Sasaki, S. Jacobsen. Immunity, 2001
784 citations recorded by the source corpus.
Subfields: Hematology, Immunology
View Paper: https://www.semanticscholar.org/paper/021deae0729140229734a583d2e365082f7e9cb2
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In Hematology
- Irving L. Weissman
- Derrick J. Rossi
- Benjamin L. Ebert
- A. Wagers
- A. Trumpp
- David Bryder
- Anne Wilson
- Mikael Sigvardsson
In Immunology
Citations in the corpus
- Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. (2009, neutral): “are in G0. As expected, MPPs expressing CD48 and CD135 are highly proliferative (26% S + G2/M and 16% G0 )( Figure 1B) ( Adolfsson et al., 2001; Weissman, 2000; Wilson et al., 2007).”
- c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation. (2004, background): “As it has recently been shown that functional LT-HSC activity is exclusively contained within the Flk2/Flt3R (CD135) subset of the KLS population (c-KitlinSca1Flk2 (KLSF) (Adolfsson et al. 2001; Christensen and Weissman 2001), the proportion of KLS cells expressing this receptor was determined.”
- Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. (2007, background): “The minor c-kit+Lin Sca1+ (KLS) compartment can be resolved into functionally distinct subsets based on differential expression of CD34 and flk2 (Adolfsson et al., 2001; Christensen and Weissman, 2001; Yang et al., 2005).”
- Single-cell RNA-seq reveals changes in cell cycle and differentiation programs upon aging of hematopoietic stem cells (2015, background): “Flt3 and Cd34 have been implicated in HSC differentiation (Osawa et al. 1996; Adolfsson et al. 2001; Yang et al. 2005; Buza-Vidas et al. 2011) and are expressed at lower levels in old versus young LT-HSCs.”
- The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. (2013, background): “The receptor for Flt3L, Flt3 (also termed CD135 and Flk2), is expressed on short-term repopulating hematopoietic stem cells (HSCs) (93), CLPs, and a subset of CMPs (73).”