The role of tumour‐associated macrophages in tumour progression: implications for new anticancer therapies

By L. Bingle, Noam Brown, C. Lewis. Journal of Pathology, 2002

2,088 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/020bf06b240b88df85e7e2abc10347ef69d5253e

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In Immunology

1. A. Mantovani
2. J. Pollard
3. Lisa M. Coussens
4. P. Allavena
5. A. Sica
6. F. Balkwill
7. D. Hanahan
8. C. Garlanda

Citations in the corpus

• The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients (2012, methodology): “reported that the majority of publications on TAMs in cancer (including breast cancer) reported a correlation between high TAM infiltration and poor patient outcome [8-11].”
• CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages (2015, background): “There are a large numbers of clinical studies that indicate a strong correlation between poor prognosis of the disease and high infiltration of macrophages in the tumor (Bingle et al., 2002; Knowles and Harris, 2007).”
• The tumor microenvironment at a glance (2012, background): “There is pre-clinical and clinical evidence that an abundance of TAMs in the TME is associated with poor prognosis (Bingle et al., 2002).”
• Macrophages Sequentially Change Their Functional Phenotype in Response to Changes in Microenvironmental Influences1 (2005, background): “Animals bearing metastatic tumors have been reported to develop a unique subset of macrophages that accumulate in the tumor mass as well as in distal sites such as the spleen and peritoneal cavity and that suppress inflammatory and immune responses (14, 30, 31).”
• Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression (2007, background): “This regulation is exemplified by positive correlations between numbers of innate immune cells (macrophages, mast cells and neutrophils) infiltrating human tumors with the number of blood vessels [81,82], and by experimental findings in mouse models where attenuating innate immune cell infiltration ”
• Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature (2012, background): “For long a large number of studies have been focused on identifying the prognostic value of TAM in solid tumors and most studies suggest that TAM is beneficial for tumor growth and, therefore, associated with poor prognosis [1].”
• Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells (2011, background): “Among these functional states, M2 macrophages activated by IL-4 have been associated with breast cancer invasion, metastasis and poor patient prognosis [2,6-10].”
• Comprehensive analyses of tumor immunity: implications for cancer immunotherapy (2016, background): “TAM numbers have been reported to be a predictor of worse outcome in many cancers [13].”