Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

By Y. S. Lee, W. Kim, K. Kim, Myung-Joo Yoon, H. J. Cho, Yun-Jie Shen, Jiming Ye, Chul-Ho Lee, W. Oh, C. Kim and 5 more. Diabetes, 2006

1,076 citations recorded by the source corpus.

Subfields: Artificial Intelligence, Information Systems, Management Information Systems

View Paper: https://www.semanticscholar.org/paper/01c220fbedeefc17aa76d1de54d3bd835a814dfc

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1. D. Hardie
2. S. Hawley
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4. Bruce E. Kemp
5. Jianping Ye
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7. K. Green
8. M. Towler

Citations in the corpus

• AMPK in Health and Disease. (2009, background): “Since the constitutively active AMPK fragment 1 (1-312) is not activated by the PT1 compound, it is proposed that PT1 acts by reversing the autoinhibition of the AIS (313-335).”
• AMPK - a nutrient and energy sensor that maintains energy homeostasis (2012, neutral): “) and plant products used in traditional Chinese medicine (berberin”
• The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model (2009, background): “Others revealed that the underlying mechanism for berberine improves insulin resistance and lowers blood sugar possibly through activating the AMPactivated protein kinase (AMPK) pathway [21].”
• Efficacy of berberine in patients with type 2 diabetes mellitus. (2008, background): “Compared to other products from GRAS plants, berberine is a single purified compound, and has glucose-lowering effect in vitro and in vivo [3-6].”
• AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. (2011, background): “…epigallocatechin gallate from green tea [Hwang et al. 2007]), and some are plant products used in traditional herbal medicines in Europe (e.g., galegine, from which metformin was originally derived) (Mooney et al. 2008) or Asia (e.g., berberine [Lee et al. 2006] and hispidulin [Lin et al. 2010]).”
• Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation (2010, background): “, 2005); and (5) phytochemicals derived from traditional medicines, such as berberine (Lee et al., 2006), or present in foods or beverages, such as quercetin (Ahn et al.”