Thiol chemistry and specificity in redox signaling.

By C. Winterbourn, M. Hampton. Free Radical Biology & Medicine, 2008

1,195 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/01b8aecd93f0ffa4bef9f28e49fd51d25e43c102

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. P. Nagy
2. Navdeep S. Chandel
3. V. Lushchak
4. S. Maggini
5. A. Carr
6. I. Peluso
7. F. Altieri
8. C. Winterbourn

In Molecular Biology

1. Navdeep S. Chandel
2. P. Nagy
3. Lucas B. Sullivan
4. V. Lushchak
5. I. Peluso
6. F. Altieri
7. C. Winterbourn
8. S. Maggini

Citations in the corpus

• Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, neutral): “Also, at low levels, hydrogen peroxide plays a role as a second messenger in signal transduction by modulating the oxidation state of redox-sensitive cysteines (Cys) to promote kinase function (133, 284, 390).”
• Mitochondrial reactive oxygen species and cancer (2014, background): “GPXs also are highly active, although less abundant, and may be an important antioxidant mechanism at higher concentrations of hydrogen peroxide [22].”
• Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans (2017, background): “Thus, cysteine oxidation by ROS depends on the protein context and provides the basis for selective and specific modifications [279, 280].”
• ROS-dependent signal transduction (2014, background): “In contrast to PRXs, GPXs have higher rate constants but are less abundant; therefore, they are likely to function only during oxidative stress when the intracellular levels of H2O2 are elevated [14].”
• Role of ROS and Nutritional Antioxidants in Human Diseases (2018, background): “Numerous studies have stressed the need for a more precise description of the metabolism of ROS in aspects of quantity, reactivity, location, and reaction kinetics (Winterbourn and Hampton, 2008; Forman et al., 2014; Margaritelis et al., 2016).”
• Environmentally induced oxidative stress in aquatic animals. (2011, background): “Being relatively on-specific, free radicals may be involved in particular pathways ue to the specificity of especially designed sensor molecules and ignal transducers (Winterbourn and Hampton, 2008).”
• Anti-apoptosis and cell survival: a review. (2011, background): “It should be noted that the term ROS refers to a number of different physiologically relevant molecules including superoxide anions (O2 2), hydrogen peroxide (H2O2), free hydroxyl radicals (OH ), nitric oxide (NO ) as well as some combinations of ROS (i.e., NO and O2 2) can yield new species such as”
• Redox chemistry of biological thiols (2010, methodology): “In a recent review article, we have attempted to model the partitioning of H2O2 between the above-mentioned thiol proteins and GSH, using published intracellular thiol concentrations (in a typical mammalian cell) and their reactivities with H2O2 assuming a homogenous system (see Figure 1) [5].”