Toxicity of Metal Oxide Nanoparticles in Mammalian Cells

By Hueiwang Anna Jeng, J. Swanson. Journal of Environmental Science and Health. Part A: Toxic/Hazardous Substances and Environmental Engineering, 2006

787 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Developmental Neuroscience, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/01b7cf2a88c68927b498ac65288748ba52216304

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In Biomedical Engineering

1. Lingling Zhang
2. J. Zink
3. M. Liong
4. Yulong Ding
5. M. Imran Rafiq
6. Tian Xia
7. S. Jin
8. Chengrong Li

In Developmental Neuroscience

1. S. Jin
2. T. R. Pisanic
3. V. Shubayev

In Materials Chemistry

1. A. Nel
2. Tian Xia
3. M. Liong
4. J. Zink
5. S. K. M. Bakhori
6. Yulong Ding
7. Habsah Hasan
8. M. Imran Rafiq

Citations in the corpus

• Zinc Oxide Nanoparticles for Selective Destruction of Tumor Cells and Potential for Drug Delivery Applications (2010, background): “All three of these levels have been observed for ZnO nanoparticles in immortalized phagocytic or bronchial epithelial cells, leading to damage of lipids, proteins and DNA, increased release of lactate dehydrogenase, and death by either necrosis or apoptosis [2,12,37,42,43].”
• Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism (2015, background): “Increased cell death achieved by increasing ZnO concentrations, which disrupt mitochondrial function, stimulating lactate dehydrogenase leakage and changing the morphology of the cell at concentrations of 50–100 mg L [90].”
• NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. (2009, background): “Exposure to ZnO NPs has been associated with inflammatory responses [9] and cytotoxicity [81], but there is only one study that has considered the DNA damaging potential of ZnO NPs.”
• Acute toxicities of six manufactured nanomaterial suspensions to Daphnia magna (2009, background): “Lovern and Klaper (2006) estimated that the lethal concentrations of C60 fullerenes (48-h LC50) to Daphnia were between 460 lg/L and 7.”
• A Review on Properties, Opportunities, and Challenges of Transformer Oil-Based Nanofluids (2016, background): “The studies indicate that high concentration ZnO nanoparticle is highly toxic and alumina nanoparticles are moderately toxic and magnetite nanoparticles are slightly toxic [115].”
• ANTIBACTERIAL ACTION OF ZINC OXIDE NANOPARTICLES AGAINST FOODBORNE PATHOGENS (2011, background): “Metal oxide nanomaterials increased cell death with increasing concentrations, affected mitochondrial function, induced lactate dehydrogenase leakage and generated abnormal cell morphology at concentrations as low as 50–100 mg/L (Hussain et al. 2005; Jeng and Swanson 2006; Chen et al. 2007).”
• Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties (2008, positive): “ticles are toxic to several cell types under tissue culture conditions.(28,29) We further demonstrate that”
• Potential toxicity of superparamagnetic iron oxide nanoparticles (SPION) (2010, background): “Mechanisms associated with toxicity SPION have attracted much attention not only because of their superparamagnetic properties but also because they have been shown to be associated with low toxicity in the human body (12, 13, 39, 40).”