Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2.

By Bennett G. Novitch, Albert I. Chen, T. Jessell. Neuron, 2001

642 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0186517666ce864d27acc71aca2f401bbfa5cde9

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Citations in the corpus

Directed differentiation of embryonic stem cells into motor neurons. (2002, methodology): “EBs were fixed, sectioned, and processed for immunohistochemistry (Novitch et al., 2001), with antibodies noted in Supplemental Data at end of paper.”
Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension. (2003, result): “…data show that retinoid signaling is necessary for paraxial mesoderm to progenitors (Pax6 [Ericson et al., 1997b]; Olig2 [Mizu- guchi et al., 2001; Novitch et al., 2001; Takebayashipromote neuronal differentiation and are consistent with observations made in VAD quails, which revealed a re- et…”
The bHLH transcription factor Olig2 promotes oligodendrocyte differentiation in collaboration with Nkx2.2. (2001, background): “Consistent with this, Olig2 alone promoted preco- cious differentiation of MBP cells when expressed in intact Olig2 to promote motoneuron differentiation (Novitch et al., 2001).”
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification. (2002, positive): “…of distinct neuronal subtypes, initiates motoneurondifferentiation and cellcycle arrest, in addition to subtypes of astroglia and perhaps of oligo-in part by promoting expression of Ngn2 (Mizuguchi et dendroglia as well (Raff, 1989; Woodruff et al., 2001). al., 2001; Novitch et al., 2001).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “Data indicating that OLIG proteins function as transcriptional repressors show that the transcriptional targets of OLIG proteins might themselves be antagonists of motor neuron or oligodendrocyte development, such that OLIG proteins promote a neuron or glial-cell fate by repressing the repressors of”
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. (2002, neutral): “and other homeodomain proteins in the ventral neural tube (Mizuguchi et al., 2001; Novitch et al., 2001).”
Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network (2008, neutral): “7A) have also been identified (Novitch et al., 2001; Vallstedt et al., 2001).”
Vertebrate neurogenesis is counteracted by Sox1–3 activity (2003, background): “Proneural bHLH proteins have been shown to promote neurogenesi”
Cortical neurons arise in symmetric and asymmetric division zones and migrate through specific phases (2004, background): “GABAergic interneurons and glial precursor cells generated in the ventral telencephalon are known to migrate tangentially into dorsal regions of the developing cerebral corte”