Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4

By Y. Junker, S. Zeissig, Seong-Jun Kim, D. Barisani, H. Wieser, D. Leffler, V. Zevallos, T. Libermann, S. Dillon, T. Freitag and 2 more. Journal of Experimental Medicine, 2012

609 citations recorded by the source corpus.

Pest resistance molecules, α-amylase/trypsin inhibitors from wheat, activate innate immune cells through engagement of TLR4 to elicit inflammatory responses in the intestine.

Subfields: Gastroenterology, Surgery

View Paper: https://www.semanticscholar.org/paper/f4a522ef6218e0fdecd58840b0f9f5ef70b22b89

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Citations in the corpus

• Does wheat make us fat and sick (2013, background): “The very recent studies of Schuppan et al. (2012) and Junker et al. (2012) on “cereal triggers of innate immune activation” describe the role of wheat amylase-trypsin inhibitors (ATIs), which probably confer defence against pests and parasites by inhibiting their digestive enzymes.”
• Celiac disease: a comprehensive current review (2019, background): “Alpha-amylase/trypsin inhibitors – molecules conferring pest resistance in wheat – also seem to play a key role in CD innate immune response by engaging the Toll-like receptor 4–MD2–CD14 complex with subsequent upregulation of maturation markers and release of proinflammatory cytokines in cells from”