Aquaporin‐4 facilitates reabsorption of excess fluid in vasogenic brain edema

By M. C. Papadopoulos, G. Manley, S. Krishna, A. Verkman. The FASEB Journal, 2004

771 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/0116e7234250ce06fa35a13101c39ba7252fd6b8

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Citations in the corpus

Physiological roles of aquaporin-4 in brain. (2013, background): “These recent data tie in with the early finding that intracerebral liquid injections produce a more acute ICP increase in Aqp4 / animals than in wild-type controls (140).”
Astrocytes: biology and pathology (2009, background): “Although excess uptake of water through AQP4 on astrocyte endfeet can lead to cytotoxic edema [135, 157, 264], the loss of astrocytes or the failure of astrocyte AQP4 channels can also lead to vasogenic edema or accumulation of extracellular fluid [33, 157, 177, 264].”
The neurodevelopmental hypothesis of schizophrenia, revisited. (2009, positive): “Aquaporin 4 is localized to astrocytes and ependymal cells in brain and is involved with water transport.(76,77) Aquaporin 4 protein expression is significantly decreased at postnatal day 35 in neocortex in BALB/c mice following infection at E9(78) possibly resulting in altered cell morphology.”
Aquaporin water channels in the nervous system (2013, positive): “It has also been suggested that AQP4 may facilitate the uptake of amyloid-β into astrocytes (Nanjing) 158 and AQP9 may facilitate the uptake of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) into substantia nigra neurons (Oslo) 159 .”
More than just water channels: unexpected cellular roles of aquaporins (2005, background): “However, brain swelling, intracranial pressure and clinical outcome are worse in AQP4-null mice (compared with wildtype mice) in models of vasogenic edema including intraparenchymal fluid infusion, cortical freeze injury, brain tumor and brain abscess (Papadopoulos et al., 2004; Bloch et al., 2005).”
Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury (2014, result): “This notion is consistent with observations in other experimental models of vasogenic edema that report exacerbation of injury with Aqp4 gene knock-out (Papadopoulos et al., 2004).”
Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption (2005, methodology): “In some mice, 5 µl PBS containing 10 5 B16F10 cells was stereotactically injected into the right cerebral hemisphere as describe”
The blood–brain barrier in systemic infection and inflammation (2021, background): “In sharp contrast to cytotoxic edema, aquaporin-4 has a protective role, mediating water efflux during conditions associated with vasogenic edema such as central nervous system injury or contusion [174], brain infection [175], and cancer [176].”