Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

By S. Saadoun, M. C. Papadopoulos, M. Hara-Chikuma, A. Verkman. Nature, 2005

730 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Plant aquaporins: membrane channels with multiple integrated functions. (2008, background): “Finally, and although the field of aquaporin research has already enlarged considerably, we may not be at the end of our surprises because novel primary functions as diverse as cell proliferation (117) or virus replication (69) might be anticipated for plant aquaporins.”
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer (2009, background): “AQP1-null mice show a dramatic reduction in the tumour growth rate and a decrease in cell migration and metastatic potential that suggest that AQP1 is a promising anticancer target [260].”
Aquaporin water channels in the nervous system (2013, positive): “…the migration of such cells can be modulated by changes in extracellular osmolality and transcellular osmotic gradients 97,100 , AQP expression increases the migration in multiple cell types and with different AQPs, and AQP expression increases lamellipodial ruffling and dynamics 94,97 .”
More than just water channels: unexpected cellular roles of aquaporins (2005, background): “Investigation of a possible role of AQP1 in tumor angiogenesis has revealed an unanticipated function of AQPs in cell migration (Saadoun et al., 2005).”