Evidence for an Independent and Cumulative Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Endothelial Dysfunction and Oxidative Stress Generation: Effects of Short- and Long-Term…

By Antonio Ceriello, C. Taboga, L. Tonutti, L. Quagliaro, L. Piconi, B. Bais, R. Da Ros, E. Motz. Circulation, 2002

711 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Endocrinology, Diabetes and Metabolism

View Paper: https://www.semanticscholar.org/paper/0023b32e16b4e1c79a05b2ac816cac9ddb9f4c3b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cardiology and Cardiovascular Medicine

1. V. Basevi
2. Marja-Riitta Taskinen

In Endocrinology, Diabetes and Metabolism

1. V. Basevi
2. I. Shimomura
3. M. Matsuda
4. Marja-Riitta Taskinen
5. Antonio Ceriello
6. Silvio E. Inzucchi
7. I. Hirsch
8. M. S. Kirkman

Citations in the corpus

• Postprandial hyperglycemia and diabetes complications: is it time to treat? (2005, background): “The main advantage of the OGTT is its simplicity: a single plasma glucose measurement 2 h after a glucose load determines whether glucose tolerance is normal, impaired, or indicative of overt diabetes.”
• Oscillating Glucose Is More Deleterious to Endothelial Function and Oxidative Stress Than Mean Glucose in Normal and Type 2 Diabetic Patients (2008, background): “Endothelial dysfunction is predictive of a future cardiovascular event (7), and evidence indicates that hyperglycemia induces endothelial dysfunction through an oxidative stress (8), which is a key player in the development of diabetes complications (9).”
• Standards of Medical Care in Diabetes—2013 (2012, background): “In diabetic subjects, some surrogate measures of vascular pathology, such as endothelial dysfunction, are negatively affected by postprandial hyperglycemia (103).”
• Standards of Medical Care in Diabetes—2014 (2013, background): “In diabetic subjects, surrogate measures of vascular pathology, such as endothelial dysfunction, are negatively affected by postprandial hyperglycemia (101).”
• Cardiovascular actions of insulin. (2007, background): “Indeed, a high-fat meal is associated with elevated circulating levels of nitrotyrosine in insulin-resistant individuals (226).”
• Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes – Mechanisms, Management, and Clinical Considerations (2016, neutral): “Even short exposure to high glucose concentrations is sufficient to reduce NO bioavailability and endothelial dependent vasodilation.(42,51,152) Endothelial dysfunction may be an independent risk marker for cardiovascular events.”
• Dietary factors and low-grade inflammation in relation to overweight and obesity (2011, neutral): “Ceriello et al.((652)) observed that after”
• Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies (2015, background): “Low levels of circulating high-density lipoprotein (HDL), increased clearance of HDL particles, higher levels of postprandial triglycerides, and elevated levels of LDL induce ROS generation in the endothelium.(131) Elevated ROS can directly cause damage to lipids, proteins, or DNA molecules and ther”
• Standards of Medical Care in Diabetes—2008 (2008, background): “In diabetic subjects, some surrogate measures of vascular pathology, such as endothelial dysfunction, are negatively affected by postprandial hyperglycemia (46).”
• Diabetic dyslipidaemia: from basic research to clinical practice* (2003, background): “A number of studies have shown that postprandial lipemia is linked with the endothelial dysfunction and generation of oxidative stress in Type 2 diabetic patients [92, 93, 94, 95].”
• Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. (2013, background): “Several studies have demonstrated that postprandial increases in triglycerides induce oxidative stress in the endothelium, which promotes proinflammatory processes and adversely affects several endothelial functions [82—85].”
• Standards of Medical Care in Diabetes—2012 (2011, background): “In diabetic subjects, some surrogate measures of vascular pathology, such as endothelial dysfunction, are negatively affected by postprandial hyperglycemia (91).”