Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells.

By Jenny Hsieh, K. Nakashima, Tomoko Kuwabara, Eunice Mejia, Fred H. Gage. Proceedings of the National Academy of Sciences of the United States of America, 2004

721 citations recorded by the source corpus.

Subfields: Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/ffde2d7d646c37b04fb55536f12720b9e1612c47

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Citations in the corpus

Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells (2006, background): “Finally, the developmentally critical basic helix–loop–helix transcription factor, NeuroD, has been shown to be involved in adult hippocampal neurogenesis (Hsieh et al. 2004).”
Identification of Astrocyte-expressed Factors That Modulate Neural Stem/Progenitor Cell Differentiation (2006, positive): “To detect neuronal differentiation of NSPCs, we used promoter activity analysis of NeuroD1, a basic helix–loop–helix transcriptional factor that is expressed when NSCs initiate their neuronal differentiation (36,37) (T. Kuwabara and F.H. Gage, unpublished observation).”
Epigenetic choreographers of neurogenesis in the adult mammalian brain (2010, background): “Inactivation of HDAC activities by HDAC inhibitors leads to marked enhancement of neuronal differentiation from adult neural stem cells in the SG”
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis (2009, positive): “Previously, we found that overexpression of NeuroD is sufficient to promote neuronal differentiation in adult hippocampal neural progenitor”
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline (2007, methodology): “RNA isolation from the obtained tissue and cDNA synthesis were performed as described previously (Hsieh et al., 2004).”
REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. (2005, background): “This role for HDAC may help explain the recent finding that inhibition of HDAC activity in adult hippocampal neural progenitors is sufficient to induce neuronal differentiation ( Hsieh et al., 2004 ).”
Environmental Influence on L1 Retrotransposons in the Adult Hippocampus (2009, result): “Moreover, immunostaining revealed that, after both treatments, most of the EGFP-positive cells colocalized with neuronal markers, consistent with recent reports demonstrating that epigenetic modifications accompany neuronal differentiation of neural stem cells (Hsieh and Gage, 2004; Hsieh et al., 20”