Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses.

By Teunis B. Geijtenbeek, R. Torensma, S. J. Vliet, G. Duijnhoven, G. Adema, Y. Kooyk, C. Figdor. Cell, 2000

1,856 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells (2003, background): “For example, prior work showed that immature DCs were much more susceptible to DV infection than their mature counterparts (5‐10-fold higher levels; reference 9), and we found that the expression of DC-SIGN mean fluorescence intensity (MFI) was threefold higher on immature DCs (MFI � 175 � 49, n � 4”
Dendritic-cell interactions with HIV: infection and viral dissemination (2006, background): “These immature MDDCs have similar characteristics to myeloid DCs, immature dermal DCs and interstitial DCs, and they express large amounts of the cell-surface markers CD11c , CD25 , DC-specific intercellular adhesion molecule 3 (ICAM3)-grabbing non-integrin ( DC-SIGN ; also known as CD209) and MHC”
Microbial stimulation fully differentiates monocytes to DC-SIGN/CD209+ dendritic cells for immune T cell areas (2010, methodology): “DC-SIGN is a hallmark of human Mo-DCs in culture (Geijtenbeek et al., 2000b) but is not detected on the rich network of presumably monocyte-independent DCs in human LNs in the steady state (Granelli-Piperno et al., 2005).”
C-type lectin receptors on dendritic cells and langerhans cells (2002, neutral): “DC-SIGN was originally defined as an intercellular adhesion molecule-3 (ICAM-3) receptor supporting DC-mediated T-cell proliferatio”