DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells
By B. Tassaneetrithep, T. Burgess, A. Granelli‐Piperno, C. Trumpfheller, J. Finke, Wellington Sun, M. Eller, K. Pattanapanyasat, S. Sarasombath, D. Birx and 3 more. Journal of Experimental Medicine, 2003
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Dengue virus is a single-stranded, enveloped RNA virus that productively infects human dendritic cells (DCs) primarily at the immature stage of their differentiation. We now find that all four serotypes of dengue use DC-SIGN (CD209), a C-type lectin, to infect dendritic cells. THP-1 cells become susceptible to dengue infection after transfection of DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), or its homologue L-SIGN, whereas the infection of dendritic cells is blocked by anti–DC-SIGN antibodies and not by antibodies to other molecules on these cells. Viruses produced by dendritic cells are infectious for DC-SIGN– and L-SIGN–bearing THP-1 cells and other permissive cell lines. Therefore, DC-SIGN may be considered as a new target for designing therapies that block dengue infection.
Subfields: Infectious Diseases, Public Health, Environmental and Occupational Health, Virology
View Paper: https://www.semanticscholar.org/paper/ac588cbbbe8105bdf14b497584292dbf8cc9c67c
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Citations in the corpus
- Structure of the dengue virus envelope protein after membrane fusion (2004, background): “5a ); there is evidence for glycan-mediated interactions as wel”
- Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion (2016, background): “In addition to this conserved functionality, alpha-, flavi-, and phleboviruses are also united in their ability to recognize DC-SIGN receptor to enable viral attachment (42, 43), a recognition event facilitated by the presentation of oligomannose-type carbohydrates on the viral surface.”
- A structural perspective of the flavivirus life cycle (2005, background): “DC-SIGN (dendritic-cell-specific ICAM-grabbing non-integrin), GRP78/BiP (glucose-regulating protein 78), and CD14-associated molecules have been suggested as primary receptors for dengue viru”