Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores

By Joseph A. Sorg, A. Sonenshein. Journal of Bacteriology, 2008

719 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/1b957813384e9197d78c82461f7169c7b7471d82

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Sunil K. Lal
2. C. Hill
3. Z. Y. Kho

In Infectious Diseases

1. C. Hill

Citations in the corpus

• Mechanisms and consequences of intestinal dysbiosis (2017, background): “difficile is facilitated by some bile acids found in the duodenum, such as taurocholate and deoxycholate [234].”
• Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome (2008, background): “difficile and other gut pathogens was proposed (30).”
• The Human Gut Microbiome – A Potential Controller of Wellness and Disease (2018, background): “Primary bile acids (cholate derivatives) serves as germinant for C. difficile spores, whereas secondary bile acids (deoxycholate) inhibits vegetative growth of C. difficile (Sorg and Sonenshein, 2008).”
• Consequences of bile salt biotransformations by intestinal bacteria (2016, background): “difficile spore germination.(123) Additional studies by Sorg J.”