Invasive Candidiasis.

By B. Kullberg, M. Arendrup. New England Journal of Medicine, 2019

1,694 citations recorded by the source corpus.

Invasive candidiasis is the most common fungal disease among hospitalized patients in the developed world. Invasive candidiasis comprises both candidemia and deep-seated tissue candidiasis. Candidemia is generally viewed as the more common type of the disease, and it accounts for the majority of cases included in clinical trials. Deep-seated candidiasis arises from either hematogenous dissemination or direct inoculation of candida species to a sterile site, such as the peritoneal cavity (Fig. 1). Mortality among patients with invasive candidiasis is as high as 40%, even when patients receive antifungal therapy. In addition, the global shift in favor of nonalbicans candida species is troubling, as is the emerging resistance to antifungal drugs. During the past few years, new insights have substantially changed diagnostic and therapeutic strategies.

Subfields: Epidemiology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/ff44b0436275e8511a64e887cdde44a9a8d25389

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. M. Pfaller
2. D. Diekema
3. Mariana Castanheira
4. Ronald N. Jones
5. J. Turnidge
6. M. Arendrup
7. J. Guinea

In Infectious Diseases

1. M. Pfaller
2. D. Diekema
3. Mariana Castanheira
4. J. Turnidge
5. Ronald N. Jones
6. M. Arendrup
7. J. Guinea

Citations in the corpus

• Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision (2017, background): “Candidaemia is the most common form of invasive candidiasis associated with an unacceptably high mortality rates in excess of 40% even with the introduction of newer antifungal agents [30,32,33].”
• Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment (2017, background): “Candida albicans is still a leading cause of candidemia, but other species (non-albicans) of Candida now comprise >50% of bloodstream infections in many parts of the world [1].”
• DANMAP 2016 - Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, food and humans in Denmark (2017, background): “There are several risk factors and risk groups associated with candidaemia such as: critically ill patients with long stay at intensive care departments, patients who undergo abdominal surgery, patients with haematologic malignancies or cancer, transplant recipients, patients treated with broad-spec”
• Twenty Years of the SENTRY Antifungal Surveillance Program: Results for Candida Species From 1997–2016 (2019, background): “glabrata as a cause of BSI is potentially related to many disparate factors in addition to fluconazole exposure, including geography, patient age, and other characteristics of the patient population studied [6, 16, 24, 26, 55, 56].”
• Antimicrobial Actions and Applications of Chitosan (2021, background): “albicans is the most frequently isolated fungal pathogen in humans [197,198].”