Molecular mechanisms of T cell co-stimulation and co-inhibition

By Lieping Chen, D. Flies. Nature reviews. Immunology, 2013

2,955 citations recorded by the source corpus.

Co-stimulatory and co-inhibitory receptors have a pivotal role in T cell biology, as they determine the functional outcome of T cell receptor (TCR) signalling. The classic definition of T cell co-stimulation continues to evolve through the identification of new co-stimulatory and co-inhibitory receptors, the biochemical characterization of their downstream signalling events and the delineation of their immunological functions. Notably, it has been recently appreciated that co-stimulatory and co-inhibitory receptors display great diversity in expression, structure and function, and that their functions are largely context dependent. Here, we focus on some of these emerging concepts and review the mechanisms through which T cell activation, differentiation and function is controlled by co-stimulatory and co-inhibitory receptors.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/ff2b0112e1bf3b7472be33f029f19a4dcccd6478

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Citations in the corpus

Advances in immunotherapy for hepatocellular carcinoma (2021, background): “I.M. receives funding from MINECO SAF2014-52361-R and SAF 2017- 83267-C2-1R; Worldwide Cancer Research Grant (15-1146); the Asociacion Española Contra el Cancer (AECC) Foundation under grant GCB15152947MELE; and the European Union’s Horizon 2020 Program (grant agreement no. 635122 PROCROP).”
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The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications (2020, background): “Immune checkpoints are molecules of coinhibitory signaling pathways that act to maintain immune tolerance, yet they are often utilized by cancer cells to evade immunosurveillance.(72,73) ICIs are designed to reinvigorate antitumor immune responses by interrupting coinhibitory signaling pathways and ”
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