Activin receptor-like kinase 1 modulates transforming growth factor-beta 1 signaling in the regulation of angiogenesis.
By S. P. Oh, T. Seki, Kendrick A. Goss, T. Imamura, Y. Yi, P. Donahoe, Li Li, K. Miyazono, P. ten Dijke, Seong-Jin Kim and 1 more. Proceedings of the National Academy of Sciences of the United States of America, 2000
923 citations recorded by the source corpus.
Subfields: Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fed1825a7d0fb7ba579c616c74a01852eb553748
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Citations in the corpus
- Myostatin Signals through a Transforming Growth Factor β-Like Signaling Pathway To Block Adipogenesis (2003, background): “The mechanism of this intracellular block remains unclear, although the possibilities include competition for limiting quantities of the common Smad, Smad4 (55), Smad-dependent regulation of specific transcriptional events (2, 29), and TGF- -mediated activation of distinct Smad pathways through dist”
- Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. (2011, background): “Two distinct type I TGFb receptors—activin receptor-like kinase (Alk)-1 and Alk-5—are expressed in both endothelial cells and mural cells and the two receptors appear to trigger different—even opposing—cellular effects (Goumans et al., 2002, 2003; Oh et al., 2000).”
- Endoglin promotes endothelial cell proliferation and TGF‐β/ALK1 signal transduction (2004, background): “Previously, we and others have shown that ALK1 inhibits TGF-b/ALK5 signalling downstream of Smad phosphorylation (Oh et al, 2000; Goumans et al, 2003).”
- Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer (2003, background): “Endothelial cells express two TGF-β type I receptors — ALK1 and ALK5 (TβRI”