Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities

By J. Vollmer, R. Weeratna, P. Payette, M. Jurk, C. Schetter, Meike Laucht, T. Wader, Sibylle Tluk, M. Liu, H. Davis and 1 more. European Journal of Immunology, 2004

615 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fecb7da7b4b9b588df182f5570ef84ae756683ba

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Yong‐jun Liu
2. M. Gilliet
3. A. Krieg
4. W. Cao
5. N. Bhardwaj
6. Shizuo Akira
7. R. Medzhitov
8. Jacques Banchereau

In Molecular Biology

1. A. Krieg

Citations in the corpus

• Targeting Toll-like receptors: emerging therapeutics? (2010, neutral): “gov/ct2/show/NCT00403052?term=NCT00403052&rank=1">NCT00403052”
• Therapeutic potential of Toll-like receptor 9 activation (2006, background): “The capacity of the different CpG ODN classes to induce such divergent immune effects might seem surprising, because these effects all seem to result from the activation of a single receptor, TLR”
• Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “Interestingly, at the same time, Klinman and colleagues classified CpG ODNs into two main groups: D-type (now known as A-type) CpG ODNs, which stimulate IFNγ production by natural killer (NK) cells, and K-type (now known as B-type) CpG ODNs, which stimulate B-cell proliferation and B-cell IL-6 and”
• Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. (2005, positive): “It is worth noting that, for the induction of IFN-α through the TLR9/MyD88-dependent pathway, both the frequency of CpG motifs and the presence of the canonical palindromic structure present in CpG types A and C ODN are essential (56, 57).”