TGF-Beta Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia

By T. Ratliff. 2004

675 citations recorded by the source corpus.

Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/fecaaa84a5b45e82d8fb8385d656bf3c9102ba08

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Joyce
2. J. Massagué
3. B. Hinz
4. J. Pollard
5. H. Moses
6. R. Weinberg
7. Binzhi Qian
8. Xiumin Wu

In Oncology

1. J. Joyce
2. J. Massagué
3. R. Weinberg
4. J. Pollard
5. B. Hinz
6. Binzhi Qian
7. D. Hanahan
8. H. Moses

In Pathology and Forensic Medicine

1. B. Hinz
2. J. Joyce
3. J. Massagué
4. A. Ostman
5. H. Moses
6. G. Gupta
7. K. Pietras

Citations in the corpus

• Therapeutic targeting of the tumor microenvironment. (2005, positive): “…protein (FAP) (Garin-Chesa et al., 1990; Park et al., 1999), CXCL12/ stromal derived factor-1 (Allinen et al., 2004; Orimo et al., 2005), HGF (Bhowmick et al., 2004a), and cathepsin K (Allinen et al., 2004), could provide promising selective targets in the tumor stroma, with encouraging…”
• TGFβ in Cancer (2008, background): “Building on this observation, Bhowmick et al. (2004) generated mice with a targeted deletion of TGFBRII in fibroblasts.”
• Hallmarks of cancer: interactions with the tumor stroma. (2010, positive): “Direct evidence for the cancer-initiating capacity of CAFs is provided by a study by Bhowmick and colleagues, in which the TGFβ type II receptor was selectively ablated in fibroblasts by expression of the Cre recombinase from the FSP-1 promoter in genetically modified mice [15].”
• Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. (2012, background): “For example, disruption of the TGF receptor type II (TGFBR2) gene in fibroblasts results in invasive squamous cell carcinoma of the forestomach.(158) In a model of prostate cancer, loss of p53 function in fibroblasts precedes inactivation of p53 in the epithelium.”
• A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth (2009, background): “Studies in primary tumors however, have also revealed major roles for the microenvironment in modulating malignancy including significant roles for resident cells such as fibroblasts and adipocytes, as well as haematopoietic cells [8,9,10,11,12,13].”
• NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2 (2007, background): “Several signaling pathways have been implicated in EMT of Eph4 cells including ras activation and TGF-b1-activated signals (Janda et al., 2002; Bhowmick et al., 2004).”
• PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. (2009, background): “Alterations in the stroma can promote epithelial tumorigenesis (Barcellos-Hoff and Ravani, 2000; Bhowmick et al., 2004; Maffini et al., 2004).”
• Cancer metastasis: building a framework. (2006, background): “Targeted disruption of transforming growth-factor β (TGFβ) signaling in fibroblasts can induce carcinomas of the forestomach and prostate in mice (Bhowmick et al., 2004).”
• New horizons in tumor microenvironment biology: challenges and opportunities (2015, background): “Genetic alterations in stromal fibroblasts caused pathologies in the adjacent glandular epithelium, as demonstrated by FGF10 overexpression in a tissue recombination model and TGF-β type II receptor conditional elimination in transgenic mice [24,25].”