Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.

By C. Huh, V. Factor, Aránzazu Sánchez, K. Uchida, E. Conner, Snorri Thorgeirsson. Proceedings of the National Academy of Sciences of the United States of America, 2004

750 citations recorded by the source corpus.

Subfields: Hepatology, Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/fe83a4e67b7d9d58553cdda85d389de5dd08a49a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Hepatology

1. Lewis R. Roberts
2. G. Michalopoulos
3. T. Roskams
4. Ming-Sound Tsao
5. S. Organ

In Oncology

1. V. Mittal
2. Lewis R. Roberts
3. W. Birchmeier
4. D. Lyden
5. J. Talmadge
6. I. J. Fidler
7. J. Joyce
8. Pengfei Lu

In Surgery

1. G. Michalopoulos

Citations in the corpus

• MET signalling: principles and functions in development, organ regeneration and cancer (2010, background): “Accordingly, conditional deletion of MET in the liver results in impaired organ reconstitution after toxic insult and hepatectom”
• Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration (2010, positive): “Among the known hepatic trophogens 10 , 18 , 26 - 28 , the expression of Wnt2 and HGF, but not other trophogens expressed by LSECs, such as Wnt9B and thrombomodulin, were drastically diminished in Id1 −/− LSECs (Fig.”
• A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells (2006, background): “All of the HCCs in our mouse models may arise from differentiated hepatocytes as a result of overexpression of oncogenes bay hepatocyte-specific minimum Alb promoter that is fully activated between 2 and 3 weeks after birt”
• Liver regeneration (2007, background): “T argeted genetic elimination of cMet from the liver is associated with very diminished or absent regenerative response (Borowiak et al., 2004; Huh et al., 2004). h.”
• Targeting MET in cancer: rationale and progress (2012, background): “Conditional ablation of Met in hepatocytes in mice interferes with hepatocyte re-entry into S phase and cell cycle progression after partial hepatectomy, resulting in impaired proliferation and incomplete liver regeneratio”
• Liver regeneration after partial hepatectomy: critical analysis of mechanistic dilemmas. (2010, background): “As an example, targeted elimination of the HGF receptor from mouse hepatocytes leads to progressive fibro-fatty change in the livers.(33,34) When these livers are subjected to partial hepatectomy, there is a dampening of the response in the first proliferative cycle, and hepatocyte proliferation is ”