A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

By Ju-Seog Lee, Jeonghoon Heo, L. Libbrecht, I. Chu, P. Kaposi-Novák, D. Calvisi, A. Mikaelyan, Lewis R. Roberts, A. Demetris, Zong-tang Sun and 3 more. Nature Medicine, 2006

937 citations recorded by the source corpus.

Subfields: Hepatology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/36b4f0c02e090dadf38d30decfd0dedde3be3ddd

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Citations in the corpus

Histological subtypes of hepatocellular carcinoma are related to gene mutations and molecular tumour classification. (2017, background): “Thought to derive from progenitor cells, this tumour subtype shares an overlapping gene expression profile with oval cells and foetal hepatoblasts.(8) It is characterized by an adverse clinical outcome.”
EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. (2008, methodology): “AFP-positive (AFP+) HCCs have a unique gene expression signature and a poor survivaloutcome (10, 13 ).”
Integrative Transcriptome Analysis Reveals Common Molecular Subclasses of Human Hepatocellular Carcinoma (2009, result): “In addition, our classification system was superior to those reported previously (10, 11, 20, 21) when those classifiers were tested across all of the validation data sets (high confidence predictions using reported signatures were 27–75%; Supplementary Fig.”
Cholangiocarcinoma 2020: the next horizon in mechanisms and management (2020, neutral): “CCA usually shows lower vascularity than in HCC — probably as a result of its extensive stroma — which is associated with greater malignant potential 386 .”
Hepatocellular carcinoma pathogenesis: from genes to environment (2006, result): “At present, analyses of human HCCs for oval-cell markers, comparison of their gene-expression patterns with rat fetal hepatoblasts and the cellular characteristics of HCCs from various animal models have provided contrasting results about the cellular origin of HC”
A Unique Metastasis Gene Signature Enables Prediction of Tumor Relapse in Early Stage Hepatocellular Carcinoma Patients (2010, neutral): “The gene expression data of cohort 2 has been published earlier (20, 21).”
Novel advancements in the management of hepatocellular carcinoma in 2008. (2008, background): “More recently, the same group reported one additional HCC subgroup of patients with grim prognosis presenting an hepatoblatoma-like signature assumed to be of progenitor cell origin [43].”
Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets (2007, background): “Thorgeirsson and collaborators defined a hepatoblast-like subtype of HCC that exhibited the most severe prognostic characteristics(31).”
Molecular mechanisms of alcohol-mediated carcinogenesis (2007, background): “Furthermore, recent work has convincingly shown that HCCs may arise directly from oval cells and exhibit a gene-expression pattern distinct from other types of HCC but typical for oval cell”
Effect of separate sampling on classification accuracy (2014, neutral): “Numbering Article Classification problem/source of data 1 [1] Ovarian 2 [10] SRBCT 3 [20] Prediction of outcome in pediatric ALL 4 [15] DLBCL outcome prediction 5 [17] Breast cancer classification 6 [19] Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas 7 [3] Prediction of t”
Loss of miR-122 expression in liver cancer correlates with suppression of the hepatic phenotype and gain of metastatic properties (2009, neutral): “…ALD, alcoholic liver disease; HBV, hepatitis B; HCC, hepatocellular carcinoma; HCV, hepatitis C; TGF-b, transforming growth factor-b. aEither HBV or HCV infection. bFrom our previously published HCC stratification (Lee et al., 2004a, 2006; Kaposi-Novak et al., 2006; Coulouarn et al., 2008).”