Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

By J. Yudkin, Meena Kumari, S. Humphries, V. Mohamed-ali. Atherosclerosis, 2000

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Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host. (2004, neutral): “hypertension, chronic heart failure, chronic renal failure, and atherosclerosis (6-12).”
Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. (2001, background): “Elevated IL-6 levels are associated with mortality in the elderly (8), and Yudkin et al. speculated that IL-6 is the link among obesity, inflammation, stress, and coronary heart disease ( 9 ).”
Platelet activation in obese women: role of inflammation and oxidant stress. (2002, neutral): “Fasting insulin, μU/mL 10 (8-12) 10 (8-17) 27 (24-42) H = 56.”
Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or noninvasive strategy. (2001, background): “C-reactive protein 10 mg/L 557 (24) 630 (74) .”
IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (2005, background): “62 , may be a reason why IL-6 has been reported to contribute to the development of atherosclerosis through various metabolic, endothelial and coagulant mechanism”