Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women.

By José Fernández-Real, M. Vayreda, C. Richart, C. Gutiérrez, M. Broch, J. Vendrell, W. Ricart. Journal of Clinical Endocrinology and Metabolism, 2001

624 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/8f21c7e2029df72085305ee773a916547ac834f1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Gerald I. Shulman
2. Herbert Tilg
3. A. Moschen
4. M. Pinzani
5. K. Petersen
6. José Fernández-Real
7. J. Bastard
8. E. Tsochatzis

In Physiology

1. Gerald I. Shulman
2. K. Petersen
3. Herbert Tilg
4. D. Leung
5. R. Davis
6. S. Kaech
7. A. Moschen
8. Haiming Cao

Citations in the corpus

• Vitamin D Inhibits Monocyte/macrophage Pro-inflammatory Cytokine Production by Targeting Mitogen-Activated Protein Kinase Phosphatase 1 (2012, positive): “responses can damage host tissues (27, 28).”
• The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD). (2016, positive): “decline following weight loss [69,70].”
• Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes (2015, positive): “…with previous studies, which have observed that increased plasma IL-6 concentrations are strong predictors of insulin resistance in humans (Fernandez-Real et al., 2001; Glund et al., 2007; Kado et al., 1999; Mohamed-Ali et al., 1997; Petersen et al., 2006; Pickup et al., 1997; Steptoe et…”
• Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. (2002, methodology): “Interestingly, two recent studies reported such a relationship between circulating IL-6 level and insulin resistance, estimated either by the fasting insulin resistance index in a large population or by using the frequently sampled iv glucose tolerance test with the minimal model analysis in a small”
• Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis (2010, background): “IL-6 serum levels are elevated in obese patients and weight loss results in decreased IL-6 serum levels.(65,66) Enhanced TNFa expression in adipose tissue of obese subjects decreases following weight loss.”
• Insulin resistance and chronic cardiovascular inflammatory syndrome. (2003, positive): “In all of these reports, circulating IL-6 was associated with insulin resistance in men (51), in women with a mean BMI of 36 kg/m(2) (233), in hyperandrogenic women (234), and in cancer patients (231).”
• Obesity and inflammation: the linking mechanism and the complications (2016, neutral): “[37] IL-6, CRP, BP, TC, TG, FBG Atherosclerosis, insulin resistance, blood pressure”