MAPK pathways in radiation responses

By P. Dent, A. Yacoub, P. Fisher, M. Hagan, S. Grant. Oncogene, 2003

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Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. (2004, background): “In contrast, ERK MAPK is strongly activated by growth factors such as platelet-derived growth factor, as well as many other stimuli that mediate cell proliferation, differentiation, and survival.(46) Each MAPK pathway is activated by phosphorylation of threonine and tyrosine residues by upstream dua”
Mitogen-activated protein kinases in apoptosis regulation (2004, background): “Cumulative efforts from many laboratories over the past decades have elucidated the ERK signaling cascade (Sturgill et al., 1988; Boulton et al., 1990; Ahn et al., 1991; Cowley et al., 1994; Seger and Krebs, 1995; Chang and Karin, 2001; Dent et al., 2003).”
Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology (2004, background): “) are activated resulting in the transcription of downstream genes thought to be involved in the radiation response [20,69–72,85–90].”