Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology

By D. Spitz, E. Azzam, Jian Jian Li, D. Gius. Cancer Metastasis Review, 2004

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Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury (2011, background): “Ionizing radiation is a strong inducer of ROS and RNS [35].”
SIRT3 is a Mitochondrial Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism During Stress (2010, background): “Cellular exposure to exogenous genotoxic stress, such as IR, has previously been shown to induce chromosomal aberrations, and one mechanism accounting for this observation has been hypothesized to involve increased intracellular superoxide levels (Spitz et al., 2004).”
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11 (2019, background): “Radiotherapy stochastically induces oxidative damage in all cellular compartments, including the lipid membrane (10, 11).”
iArc monogrAphs on the evAluAtion oF cArcinogenic risks to humAns (2012, background): “, 1999), and to modulate the cellular level of certain redox pathways (Spitz et al., 2004).”