Human LINE retrotransposons generate processed pseudogenes

By Cécile Esnault, J. Maestre, T. Heidmann. Nature Genetics, 2000

839 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science

View Paper: https://www.semanticscholar.org/paper/fdba26b988712fb2e8bb5687c2a85d7b4d9dee55

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Haig H. Kazazian
2. T. Heidmann
3. R. Medzhitov
4. Daniel B. Stetson
5. J. S. Ko
6. J. V. Moran
7. M. G. Kidwell
8. Jose Luis Garcia-Perez

In Plant Science

1. Haig H. Kazazian
2. T. Heidmann
3. Daniel B. Stetson
4. J. S. Ko
5. R. Medzhitov
6. M. G. Kidwell
7. J. V. Moran
8. Jose Luis Garcia-Perez

Citations in the corpus

• LINE-mediated retrotransposition of marked Alu sequences (2003, result): “Third, we showed in a previous study, through an ex vivo assay, that human L1 elements can induce the retroposition of a cellular mRN”
• The evolutionary origin of orphan genes (2011, background): “Reverse transcriptase produced by retroviruses or retrotransposons can copy any mRNA into DNA, which can then be inserted back into the genom”
• Comparative and demographic analysis of orangutan genomes (2011, neutral): “The rate of processed pseudogene formation, which like Alu insertion requires functional L1 machinery 15 , was similar for the human (8.0 per Myr), chimpanzee (12.7 per Myr) and orang-utan (11.6 per Myr) lineages (Supplementary Information section 10).”
• DNA hypomethylation and human diseases. (2007, neutral): “1 million copies [74,75].”
• Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1 (2004, background): “L1 elements are the most abundant autonomous retrotransposons in the human genome and are believed to function in trans to retrotranspose Alu elements and processed pseudogene”
• Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, methodology): “…substrates of Trex1, we used two genetically marked retroelements corresponding to the two major classes of DNA fragments recovered from Trex1-deficient hearts: a human L1 element (Esnault et al., 2000) and an LTR-containing murine intracisternal type A particle (IAP; Dewannieux et al., 2004).”
• Human L1 Retrotransposition: cisPreference versus trans Complementation (2001, background): “(8) recently provided experimental evidence consistent with the notion that human L1s retrotranspose by cis preference in cultured feline cells.”
• Endogenous Viral Elements in Animal Genomes (2010, background): “In mammals, matches to RNA virus proteins that spanned complete genes were typically flanked by target site duplications (TSDs) and 39 poly-A tails, consistent with LINE-mediated retrotransposition of viral mRNAs [36].”
• Origins, evolution, and phenotypic impact of new genes. (2010, neutral): “In mammals, LINE-1 retrotransposons provide the required enzymatic machinery (Mathias et al. 1991; Feng et al. 1996; Esnault et al. 2000).”