Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1

By D. Sayah, Elena Sokolskaja, L. Berthoux, J. Luban. Nature, 2004

716 citations recorded by the source corpus.

Subfields: Cardiology and Cardiovascular Medicine, Molecular Biology, Virology

View Paper: https://www.semanticscholar.org/paper/5a10d3738f55daf62602acad6b77bd2aa7e4d313

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Citations in the corpus

• Retrotransposons revisited: the restraint and rehabilitation of parasites. (2008, neutral): “Retrotransposition of the cyclophilin gene into an intron of TRIM5 created a fusion gene that explains resistance of the owl monkey to HIV-1 infection (Sayah et al., 2004).”
• The impact of retrotransposons on human genome evolution (2009, neutral): “However, genome-wide searches have confirmed the importance of gene retrotransposition in the emergence of new primate gene”
• Retroviral Restriction Factor TRIM5α Is a Trimer (2005, background): “Owl monkeys, a New World species, do not express a TRIM5 protein but instead express TRIMCyp, which consists of the RING, B-box 2, and coiledcoil domains of TRIM5 fused with cyclophilin A (20, 28).”
• TRIM family proteins: retroviral restriction and antiviral defence (2005, background): “Third, in owl monkeys, the SPRY domain of TRIM5α has been replaced by a cyclophilin A (CypA) pseudogen”