Evaluation of abnormal liver-enzyme results in asymptomatic patients.

By D. Pratt, M. Kaplan. New England Journal of Medicine, 2000

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Decreased survival of subjects with elevated liver function tests during a 28‐year follow‐up (2010, neutral): “No-NASH (1-2) Alive (24) 12 2 0 0 10 Dead (8) 2 1 1 1 2 1 Border line (3-4) Alive (18) 10 3 0 0 5 Dead (15) 3 6 3 3 0 NASH (5-8) Alive (29) 11 12 2 1 3 Dead (24) 5 10 3 4 2”
Updated Definitions of Healthy Ranges for Serum Alanine Aminotransferase Levels (2002, background): “However, creating an equation to individualize normal limits on the basis of our multivariate analysis does not seem to be an optimal solution either because it is unlikely to be widely adopted (1).”
Liver enzyme alteration: a guide for clinicians (2005, background): “perbilirubinemia include reabsorption of large hematomas and ineffective erythropoiesis.(24)”