Liver enzyme alteration: a guide for clinicians

By E. Giannini, R. Testa, V. Savarino. Canadian Medical Association Journal, 2005

2,000 citations recorded by the source corpus.

ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.

Subfields: Epidemiology, Hepatology, Oncology

View Paper: https://www.semanticscholar.org/paper/a17298d5076fd2a19677551d27b09acb590a5b3e