The expression of vesicular glutamate transporters defines two classes of excitatory synapse.

By R. Fremeau, M. Troyer, I. Pahner, G. Nygaard, Cindy H Tran, R. Reimer, E. Bellocchio, Doris L. Fortin, J. Storm-Mathisen, R. Edwards. Neuron, 2001

1,273 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience

View Paper: https://www.semanticscholar.org/paper/fd68368b60db064210046346704067121f1940e1

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In Cell Biology

1. R. Jahn
2. R. Luján
3. T. Sūdhof

In Cellular and Molecular Neuroscience

1. Egidio D'Angelo
2. Rafael Franco
3. Andrea Volterra
4. R. Luján

Citations in the corpus

• A Third Vesicular Glutamate Transporter Expressed by Cholinergic and Serotoninergic Neurons (2002, background): “Because VGLUT3 localizes to synaptic vesicles, as do VGLUT1 and VGLUT2, we concluded that it is a novel vesicular glutamate transporter.”
• LETTER TO NEUROSCIENCE DIFFERENTIAL DISTRIBUTION OF VESICULAR GLUTAMATE TRANSPORTERS IN THE RAT CEREBELLAR CORTEX (2003, background): “VGluT1 immunoreactivity (Bellocchio et al., 1998) and VGluT2 immunoreactivity (Fremeau et al., 2001; Fujiyama et al., 2001; Herzog et al., 2001; Kaneko and Fujiyama, 2002) were electron-microscopically located on synaptic vesicles of the axon terminals which made asymmetric, putatively excitatory…”
• Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. (2005, background): “3, pyramidal cells of the medial prefrontal cortex and subiculum richly express mRNA encoding vesicular glutamate transporter-1 (VGlut1), a specific marker of glutamate neurons (c.f., Fremeau et al., 2001).”
• Molecular anatomy of a trafficking organelle. (2006, background): “These transporters display a differential localization in the brain and are known to reside on nonoverlapping vesicle subpopulations (Fremeau et al., 2001).”
• Epigenomic profiling reveals DNA-methylation changes associated with major psychosis. (2008, result): “Given the link between DNA methylation and gene transcription, our data concur with data from gene expression studies and the observation that VGLUT1 and VGLUT2 are expressed in a complementary manner in cortical neurons.(30) VGLUT1, which was hypermethylated in SZ female samples, is downregulated i”
• Astrocytes contain a vesicular compartment that is competent for regulated exocytosis of glutamate (2004, background): “This can explain why initial studies did not detect glial labelin”
• Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers (2006, background): “…A2AR immunoreactivity could be detected in single glutamatergic nerve terminals, identified by immunostaining using antibodies against vesicular glutamate transporters type 1 and 2 (vGluT1 and vGluT2), which are expressed in glutamatergic neurons (Fremeau et al., 2001; Herzog et al., 2001) (Fig.”
• Granule Cell Ascending Axon Excitatory Synapses onto Golgi Cells Implement a Potent Feedback Circuit in the Cerebellar Granular Layer (2013, background): “GrCs express exclusively vGluT1, whereas CFs express vGluT2 only (Fremeau et al., 2001; Hioki et al., 2003).”