Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials.

By M. Grundman, Ronald C. Petersen, S. Ferris, Ronald G. Thomas, P. Aisen, David A. Bennett, N. Foster, Clifford R. Jack Jr., D. Galasko, R. Doody and 14 more. Archives of Neurology, 2004

994 citations recorded by the source corpus.

Subfields: Physiology, Psychiatry and Mental health, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/fd31f30142ec988b2ee7d7303fac1be4c26d6c30

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In Physiology

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Christos Davatzikos

Citations in the corpus

Mild cognitive impairment as a clinical entity and treatment target. (2005, methodology): “In the recently completed Alzheimer’s Disease Cooperative Study Clinical Trial on MCI, 212 of the 214 subjects who progressed from MCI to dementia were characterized as having possible or probable AD, indicating that when rigorously applied, the criteria can be highly specific.(14,16) However, subse”
Convolutional Neural Networks-Based MRI Image Analysis for the Alzheimer’s Disease Prediction From Mild Cognitive Impairment (2018, background): “Mild cognitive impairment (MCI) is known as the transitional stage between normal cognition and dementia (Markesbery, 2010), about 10–15% individuals with MCI progress to AD per year (Grundman et al., 2004).”
Generative-Discriminative Basis Learning for Medical Imaging (2012, background): “[47] estimated an approximate rate of 10% to 15% per year; nevertheless not all MCI subjects converge to the AD.”
DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease (2011, result): “…Ganguli, 2006), one MCI patient made a transition to dementia with Lewy bodies and 7 MCI patients made the transition to AD, in good accordance with a rate of conversion to AD of ~ 10–16% observed per year in other studies (Grundman et al., 2004; Petersen et al., 2005; Gauthier et al., 2006).”
The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screening (2006, methodology): “…a clinical interview with the patient and an informant; and (5) not sufficiently impaired, cognitively and functionally, to meet National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer’s Disease and Related Disorders Association criteria for AD (Grundman et al., 2004).”
Abnormal Cortical Networks in Mild Cognitive Impairment and Alzheimer's Disease (2010, background): “Studies suggest that subjects with MCI tend to progress to probable Alzheimer’s disease at a rate of approximately 10% to 15% per year [7].”
Chronic stress, cognitive functioning and mental health. (2011, positive): “They also show hippocampal atrophy that falls between healthy older adults and AD patients (Grundman et al., 2004).”
Structural and functional biomarkers of prodromal Alzheimer's disease: A high-dimensional pattern classification study (2008, neutral): “Grundman et al. (2004)).”
Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice (2005, positive): “memory impairments occur with the preservation of t a other cognitive domains (Grundman et al., 2004).”