DTI measures in crossing-fibre areas: Increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease

By Gwenaëlle Douaud, Saâd Jbabdi, Timothy Edward John Behrens, R. Menke, A. Gass, A. Monsch, A. Rao, Brandon Whitcher, Gordon L. Kindlmann, Paul M. Matthews and 1 more. NeuroImage, 2011

532 citations recorded by the source corpus.

Subfields: Orthopedics and Sports Medicine, Pediatrics, Perinatology and Child Health, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/5dd8f2e93879f31b977b618e05ef8e535cfe6d3a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Orthopedics and Sports Medicine

In Pediatrics, Perinatology and Child Health

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

Apparent Fibre Density: A novel measure for the analysis of diffusion-weighted magnetic resonance images (2012, background): “Interpreting population differences in DTI-derived scalar measures such as FA or tensor eigenvalues is challenging in regions with crossing fibres (Pierpaoli et al., 2001; Tuch et al., 2005; Douaud et al., 2011).”
Diffusion MRI at 25: Exploring brain tissue structure and function (2012, background): “Complimentary indices such as dispersion of the principle diffusion direction (Douaud et al., 2009), or mode of anisotropy (Douaud et al., 2011), can potentially offer even greater insights into underlying pathology (Fig.”
The early development of brain white matter: a review of imaging studies in fetuses, newborns and infants. (2014, background): “bundles follow different maturational calendars: when the first bundle gets myelinated, anisotropy first increases, but it subsequently decreases when the second crossing bundle gets mature (the reverse argument has been detailed for neurodegenerative disorders (Douaud et al., 2011)); at the same ti”
Investigating the prevalence of complex fiber configurations in white matter tissue with diffusion magnetic resonance imaging (2013, background): “In yet another study, increased diffusion anisotropy was measured in the centrum semiovale of patients with mild cognitive impairment and mild Alzheimer’s disease [Douaud et al., 2011].”
Multimodal population brain imaging in the UK Biobank prospective epidemiological study (2016, unknown): “…exhibit the opposite, of FA increasing with aging, which may reflect degradation of secondary fibers or reduced fiber dispersion23; notably, none of the FA-based IDPs exhibit this significant positive correlation, demonstrating that averaging across tracts can sacrifice richness of information.”