A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

By Marco Y. Hein, N. Hubner, I. Poser, Jüergen Cox, Nagarjuna Nagaraj, Y. Toyoda, Igor A. Gak, Ina Weisswange, J. Mansfeld, F. Buchholz and 2 more. Cell, 2015

1,214 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fcdb788e7421b8b164510a64a10af211a941b23f

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Citations in the corpus

Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. (2019, neutral): “, 2018), consistent with the notion that PKR is an abundant protein (Hein et al., 2015).”
The high mobility group protein HMG20A cooperates with the histone reader PHF14 to modulate TGFβ and Hippo pathways (2022, background): “Inspection of high-throughput proteomic studies also suggested that HMG20A may have additional partners that could explain additional functions of the protein (14,15).”
High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies. (2018, background): “…been associated with DNA damage repair (reviewed in Zheng et al., 2015), and although some studies previously suggested its association to components of splicing, mRNA capping, or transcription elongation (e.g., Hein et al., 2015; StDenis et al., 2016), this was not systematically assessed.”
A reference map of the human binary protein interactome (2020, background): “These results reinforce previous observations 12,22 that the protein interactome might be dominated by weaker and more transient PPIs that are difficult to detect, as indicated by the fact that the majority of PPIs in HuRI were found in only one screen (Extended Data Fig.”
Network medicine framework for identifying drug-repurposing opportunities for COVID-19 (2020, methodology): “ similarity terms, using: SF1‘ # 343(S,T)=|1 #−_ # | (11) SF1‘ # 9:(S,T)=1 #logd -" C" e (12) 14 SF1‘ # <4#TAB#(S,T)=+ 0 [1logd -" 5" e+_log( C" 5" )],‘=#TAB#"* " 0 (13) These distance similarity terms collectively contribute to each drug’s ranking score. A”
OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization (2022, methodology): “We found that most proteins interact with low stoichiometry [as we previously described ( 7 )] and without strong similarities in their spatial distribution (Fig.”
A molecular grammar governing the driving forces for phase separation of prion-like RNA binding proteins (2018, neutral): “In most cases, this concentration lies above the physiological concentration in HeLa cells (Hein et al., 2015; Patel et al., 2015) of these proteins (Table S2).”