Dysfunction of endothelial protein C activation in severe meningococcal sepsis.

By S. Faust, M. Levin, Odile B. Harrison, Robert D. Goldin, M. Lockhart, S. Kondaveeti, Z. Laszik, C. Esmon, R. Heyderman. New England Journal of Medicine, 2001

691 citations recorded by the source corpus.

Subfields: Epidemiology, Hematology, Public Health, Environmental and Occupational Health

View Paper: https://www.semanticscholar.org/paper/fc7faa2b211ac0f8724effdc1ead43f273af7f9e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. Michael A. Matthay
2. T. van der Poll

In Hematology

1. H. Versteeg
2. Pieter H. Reitsma
3. J. Heemskerk
4. M. Levi
5. T. van der Poll

Citations in the corpus

• Inflammation, endothelium, and coagulation in sepsis (2008, background): “In patients with severe meningococcal sepsis, downregulation of TM and consequent impaired PC activation were confirmed in vivo by immunohistochemistry [88].”
• Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway? (2007, background): “Depletion of protein C is well described in severe sepsis.(33,37) A recent study has also identified activated protein C generation immediately following cardiac arrest.”
• Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. (2008, background): “Studies variously suggest that sTM does not reflect endothelial TM activity but is simply a marker of endothelial injury,(12) is itself active(13,14) or that it is in fact inhibitory to the accepted role of thrombomodulin.(15,16) Our data would suggest that plasma sTM levels do reflect overall throm”
• Hematologic changes in sepsis and their therapeutic implications. (2004, result): “These findings were interpreted to indicate that protein C activation is impaired, a conclusion supported by in vivo data in two patients treated with protein C concentrate.(69) However, a recent post hoc analysis of data from the PROWESS study, in which the ratio of plasma concentrations of zymogen”
• Inflammation and coagulation (2010, background): “Furthermore, a significant down-regulation of thrombomodulin, caused by proinflammatory cytokines such as TNF- and IL-1, has been demonstrated, resulting in diminished protein C activation (57, 58).”
• Guidelines for the diagnosis and management of disseminated intravascular coagulation (2009, neutral): “The natural anticoagulants antithrombin and protein C are often reduced in DIC and these have been shown to have prognostic significance (Conway & Rosenberg, 1988; Fourrier et al , 1992; Mesters et al , 1996; Faust et al , 2001).”
• New fundamentals in hemostasis. (2013, background): “Furthermore, a significant downregulation of thrombomodulin, caused by proinflammatory cytokines such as TNF- and IL-1, has been demonstrated, resulting in diminished protein C activation (91, 193).”