Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.
By K. Brohi, M. Cohen, M. Ganter, M. Schultz, M. Levi, R. Mackersie, J. Pittet. Journal of Trauma, 2008
778 citations recorded by the source corpus.
Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Hematology
View Paper: https://www.semanticscholar.org/paper/78a20df003b1aeaf7689c12669398b7a936dc0c0
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Critical Care and Intensive Care Medicine
In Epidemiology
In Hematology
Citations in the corpus
- The coagulopathy of trauma: a review of mechanisms. (2008, background): “Hyperfibrinolysis is common after trauma and is a direct consequence of both tissue injury and shock.(24) Endothelial injury results in increased fibrinolysis because of the direct Mechanisms of Traumatic Coagulopathy”
- The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition (2016, background): “The severity of the coagulation disorder is influenced by environmental and therapeutic factors that result in, or at least contribute to, acidaemia, hypothermia, dilution, hypoperfusion and coagulation factor consumption [9, 10, 18, 24–26].”
- Management of bleeding and coagulopathy following major trauma: an updated European guideline (2013, background): “On one hand, coagulopathy is influenced by environmental and therapeutic factors that result in or at least contribute to acidaemia, hypothermia, dilution, hypoperfusion and coagulation factor consumption [5,6,9,13-15].”
- Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) Study. (2012, positive): “It has an established safety and efficacy profile,(8-12) and its primary effect of inhibition of clot breakdown portends a favorable effect on patients with hemorrhage from vascular disruption.(7,13) Because plasmin is known to have proinflammatory effects, other beneficial effects have been suggest”
- Management of bleeding following major trauma: an updated European guideline (2010, background): “The condition is influenced by environmental and therapeutic factors that contribute to acidaemia, hypothermia, dilution, hypoperfusion and haemostasis factor consumption [3,4,8-11].”
- Molecular Intercommunication between the Complement and Coagulation Systems (2010, background): “The coagulation/fibrinolysis cascades and the complement system appear to be triggered simultaneously by severe tissue injury (26, 27), acute trauma (28), or during systemic inflammation (9).”