Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming

By F. Varoqueaux, A. Sigler, J. Rhee, N. Brose, Carsten Enk, K. Reim, Christian Rosenmund. Proceedings of the National Academy of Sciences of the United States of America, 2002

638 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/fc7f8a0f4097012fac87f31f712847f068e5a0ec

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Citations in the corpus

Calmodulin and Munc13 Form a Ca 2 Sensor/Effector Complex that (2004, positive): “The generation of this RRP is2 Department of Molecular Neuroendocrinology absolutely dependent on the priming action of UNC-13/Max-Planck-Institute for Experimental Medicine Munc13s (Varoqueaux et al., 2002; see below).”
Is there more to gaba than synaptic inhibition? (2002, background): “However, the brains of mice that are null for two isoforms of the synaptic vesicle protein Munc13 are devoid of both GABA- and glutamate-mediated vesicular release, but brain histogenesis and synapse development also appear to be norma”
Redundant functions of RIM1α and RIM2α in Ca2+‐triggered neurotransmitter release (2006, methodology): “We thank Dr A Ho, Dr M Khvotchev, Dr S Chandra, Dr A Becker, and Dr H Beck for helpful scientific discussions, support, and advice, S Bauerkämper, I Kornblum, A Roth, and E Borowicz for excellent technical assistance, and N Hamlin and J Mitchell for animal care.”
Activity-driven local ATP synthesis is required for synaptic function (2014, neutral): “Exocytosis relies on the correct as- sembly of SNARE proteins and can be completely eliminated at synapses by removal of the SNARE-associated protein Munc13 (Varoqueaux et al., 2002).”
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle (2013, background): “…conformation and is selectively required for synaptic vesicle priming upstream of fusion and of Ca2+ triggering of release (Augustin et al., 1999; Richmond et al., 2001; Varoqueaux et al., 2002; Ma et al., 2013), again suggesting that SNARE complexes are at least partly assembled prior to fusion.”
Compartmentalizing the neuronal plasma membrane from axon initial segments to synapses. (2009, background): “Although some experiments indicates that neuronal activity is not necessary for synapse formation during development per se (Varoqueaux et al., 2002; Verhage et al., 2000), activity is majorly involved in regulation of synaptic stabilization or elimination (Varoqueaux et al.”
Cation-chloride cotransporters and neuronal function. (2009, background): “Somewhat surprisingly, synaptogenesis and early brain development are hardly affected in knockout mice where GABA synthesis, vesicular transport, or vesicular release are eliminated (Jin et al., 1999; Varoqueaux et al., 2002; Verhage et al., 2000; Wojcik et al., 2006).”
SNAREs and traffic. (2005, background): “5; 50% dec of Syn4+/ mice Syn11 [165] Mutations caused type 4 F SNAP-25 [144] Embryonic lethality; evok Vti1b [143] No major defects but Syn proteins in hepatocytes a-SNAP [82] Mutations caused hyh (hy protein localization and co Synaptotagmin I [110] Die after birth; evoked syn Munc18-1 [145] Die a”