Iron homeostasis.

By N. Andrews, P. Schmidt. Annual Review of Physiology, 2007

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How researchers see this paper

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Ferroptosis: mechanisms and links with diseases (2021, background): “Transferrin is the primary protein responsible for iron transport.(60) The iron import starts by binding of ironbound transferrin (Fe) to transferrin receptor 1 (TFR1, recently introduced as a specific ferroptosis marker(61)) and subsequent endocytosis in endosomes.”
The Development of the Concept of Ferroptosis (2018, positive): “the iron-binding and mRNA-regulatory proteins named iron-regulatory proteins 1 and 2 (IRP1 and IRP2), that can sense the cellular concentration of free iron and respond by altering the expression of proteins governing iron export, import, storage and release [127].”
Glutaminolysis and Transferrin Regulate Ferroptosis (2015, background): “Transferrin is an iron carrier protein in serum that can be transported into the cell via receptor-mediated endocytosis (Andrews and Schmidt, 2007).”
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “84 It is delivered into cells and localized in endosomes with the assistance of TFR1, a membrane protein.”
ROLE OF IRON IN PLANT GROWTH AND METABOLISM (2015, background): “Several iron transporters are able to transport iron along with Zn and other metals (Korshunova et al., 1999; Eckhardt et al., 2001; Gross et al., 2003; Lopez-Millan et al., 2004).”
Homeostasis and toxicology of essential metals (2012, positive): “4.3C) (Andrews and Schmidt, 2007).”