The IKK complex: an integrator of all signals that activate NF-κB?

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NF‐κB activation by protein kinase C isoforms and B‐cell function (2003, neutral): “1; Israel, 2000).”
Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures. (2000, background): “The ubiquitinated IκB is itself a target for degradation by proteasomes and, once the inhibitory IκB is destroyed, the associated NF-κB is freed from restraint and can enter the nucleus and activate transcription (reviewed in Israel, 2000).”
Tetrameric Oligomerization of IκB Kinase γ (IKKγ) Is Obligatory for IKK Complex Activity and NF-κB Activation (2003, background): “Gene ablation experiments have established that IKK and IKK are required for NF-B activation by proinflammatory stimuli, while IKK is essential for morphogenic signals (11, 15 , 16).”
Functional classification of interferon‐stimulated genes identified using microarrays (2001, background): “The IKKa and IKKb kinases phosphorylate the IkB proteins, which targets them for degradation and releases the NF-kB transcription factor, which then translocates to the nucleus and activates gene expression [24–26].”
Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. (2008, background): “IKK is comprised of two catalytic subunits, IKK and IKK , and a regulatory subunit, IKK /NEMO (Israel 2000; Bonizzi and Karin 2004; Hayden and Ghosh 2004).”