Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion.

By D. Raucher, T. Stauffer, Wen D. Chen, K. Shen, Shuling Guo, J. York, M. Sheetz, T. Meyer. Cell, 2000

684 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/fba95fc61cd2796f73e4cee1238a39530bfeea20

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In Cell Biology

1. R. Grosse
2. S. McLaughlin
3. Oliver T. Fackler
4. Y. Yarden
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Citations in the corpus

• Gap43, Marcks, and Cap23 Modulate Pi(4,5p)2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism (2000, background): “According to in vitro system studies, sequestration of PI(4,5)P2 should consistently promote cell-surface actin dynamics, facilitating stimulusinduced actin recruitment, whereas its local liberation should promote growth and stabilization of peripheral actin structures (for reviews see Welch et al.,”
• Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. (2006, neutral): “Like SopB, INP54p disrupted cell-surface localization of TIRAP (Figure S4C and S4E).”
• Syndecan Recyling Is Controlled by Syntenin-PIP 2 Interaction and Arf6 (2005, background): “Restoring high affinity for IP2, by fusing the syntenin PDZ1mut N-Ter to the PH omain of PLCdelta (Raucher et al., 2000), rescued a ormal distribution of syndecan-2 (Figures 1L and 1M).”
• Cell motility through plasma membrane blebbing (2008, background): “Indeed, experimental or genetic depletion of PM PIP2 leads to vigorous PM blebbing ( Raucher et al., 2000 ; Wang et al., 2008 ).”
• Plasma membrane phosphoinositide organization by protein electrostatics (2005, background): “21 ), and laser-tweezer experiments show that PIP 2 functions as a second messenger to regulate cytoskeleton–plasma-membrane adhesio”
• Phosphotidylinositol 4,5-Bisphosphate Signals Underlie Receptor-Specific Gq/11-Mediated Modulation of N-Type Ca2+ Channels (2004, background): “However, after PLC activation, the PLC -PH increasingly translocates to the IP3 molecules accumulating in the cytosol, and this movement of EGFP fluorescence is an optical reporter of PLC activity.”
• Derailed endocytosis: an emerging feature of cancer (2008, background): “It has become increasingly apparent that PIP 2 critically regulates this proces”
• Local PIP2 signals: when, where, and how? (2007, methodology): “Using PH domains to visualize PIP2 ,t he distribution of PIP2 appears homogeneous in some cells [ 70 ], but can also appear clustered and/or localized to “speckles” in other cells.”