Cell motility through plasma membrane blebbing

By Oliver T. Fackler, R. Grosse. Journal of Cell Biology, 2008

611 citations recorded by the source corpus.

Plasma membrane blebs are dynamic cytoskeleton-regulated cell protrusions that have been implicated in apoptosis, cytokinesis, and cell movement. Influencing Rho–guanosine triphosphatase activities and subsequent actomyosin dynamics appears to constitute a core component for bleb formation. In this paper, we discuss recent evidence in support of a central role of nonapoptotic membrane blebbing for cell migration and cancer cell invasion as well as advances in our understanding of the underlying molecular mechanisms. Based on these studies, we propose that in a physiological context, bleb-associated cell motility reflects a cell's response to reduced substratum adhesion. The importance of blebbing as a functional protrusion is underscored by the existence of multiple molecular mechanisms that govern actin-mediated bleb retraction.

Subfields: Cell Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/c8a267dc214ea886da996a4f76d166a272039860

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In Cell Biology

1. A. Doyle
2. A. Ridley
3. Kenneth M. Yamada
4. R. Petrie
5. B. Cravatt
6. G. Krupitza

In Physiology

1. A. Ridley
2. Kenneth M. Yamada
3. R. Petrie
4. A. Doyle

Citations in the corpus

• Cancer invasion and the microenvironment: plasticity and reciprocity. (2011, neutral): “, 2008; Lämmermann and Sixt, 2009) and the propulsive cell migration of normal and neoplastic cells by blebs (Fackler and Grosse, 2008; Lorentzen et al., 2011; Poincloux et al., 2011).”
• Life at the leading edge. (2011, background): “Recently, blebbing has received renewed interest in themigration field with the observations thatmultiple cell typesmove by blebbing under certain conditions, including cancer cells andDictyostelium cells in vitro and several cell types in vivo (Charras and Paluch, 2008; Fackler and Grosse, 2008).”
• Random versus directionally persistent cell migration (2009, methodology): “Some cells can migrate without lamellipodia using bleb-based motilit”
• Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis (2010, background): “a Fatty Acid Network that”
• In vitro cell migration and invasion assays. (2013, background): “This is called blebby amoeboid migration [13,16,17] and is used for example by embryonic cells, leukocytes migrating through the ECM (3D migration) or by certain cancer cells.”