Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
By Hui-Ming Gao, Jau-Shyong Hong. Trends in immunology, 2008
776 citations recorded by the source corpus.
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the CNS. Substantial evidence has documented a common inflammatory mechanism in various neurodegenerative diseases. We hypothesize that in the diseased CNS, interactions between damaged neurons and dysregulated, overactivated microglia create a vicious self-propagating cycle causing uncontrolled, prolonged inflammation that drives the chronic progression of neurodegenerative diseases. We further propose that dynamic modulation of this inflammatory reaction by interrupting the vicious cycle might become a disease-modifying therapeutic strategy for neurodegenerative diseases.
Subfields: Molecular Biology, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/fba1be4bfacd28c09c40bfefc12633ed35acd1ad
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Citations in the corpus
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases (2015, background): “Neuroinflammation is a prominent feature shared by various neurodegenerative diseases such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and amyotrophic lateral sclerosis (ALS) [1–3].”
- Selective COX-1 inhibition: A therapeutic target to be reconsidered. (2010, background): “(1)), and reactive oxygen and nitrogen species, several of which contribute directly to neuronal injury [65-67].”
- Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases (2013, neutral): “Consumption of fruits and vegetables and related products, rich in anthocyanins and other (poly)phenols, is thought to reduce inflammatory stress, and as a consequence, provides some degree of protection against the development of chronic diseases, including cancer, cardiovascular, and neurodegenera”
- Role of Microglia in Neurotrauma (2010, neutral): “tion and neuronal cell death that drives the chronic progression of neurodegeneration and disease.(22)”