suspended Microchannel Resonators for Biomolecular Detection

By Thomas P. Burg, Scott R. Manalis. 2003

261 citations recorded by the source corpus.

We present a resonant mass sensor for specific biomolecular detection in a subnanoliter fluid volume. The sensing principle is based on measuring shifts in resonance frequency of a suspended microfluidic channel upon accumulation of molecules on the inside walls of the device. Confining the fluid to the inside of a hollow cantilever enables direct integration with conventional microfluidic systems, significantly increases sensitivity by eliminating high damping and viscous drag, and allows the resonator to be actuated by electrostatic forces. Fluid density measurements reveal a mass resolution of 10−17 g/μm2 in a 4 mHz–4 Hz bandwidth. To demonstrate biomolecular detection, we present real-time measurements of the specific binding between avidin and biotinylated bovine serum albumin. Based on these measurements, we expect that changes in surface mass loading on the order of 10−19 g/μm2 can be detected in an optimized system.

Subfields: Atomic and Molecular Physics, and Optics, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/fb78e12c8365fd441d1d0b7b5133770a2e9d4946

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In Atomic and Molecular Physics, and Optics

In Electrical and Electronic Engineering

Citations in the corpus

Mass transport and surface reactions in microfluidic systems (2006, methodology): “1C) are also developed as techniques for measuring adsorption kinetics (Burg and Manalis, 2003).”
Cells on chips (2006, background): “Recently described cantilever technologies look promising as mass-based sensor technique”
Cantilever-like micromechanical sensors (2011, background): “Thereby, the device can be operated in a vacuum while analysing liquids inside the cantilever structure [235].”
Vacuum-Packaged Suspended Microchannel Resonant Mass Sensor for Biomolecular Detection (2006, unknown): “[21] In SMR detection, target molecules”